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Article

More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects.

Traffic (Copenhagen, Denmark) - 1 Jun 2018

Blackburn Jessica B, Kudlyk Tetyana, Pokrovskaya Irina, Lupashin Vladimir V

Abstract excerpt

The conserved oligomeric Golgi (COG) complex controls membrane trafficking and ensures Golgi homeostasis by orchestrating retrograde vesicle trafficking within the Golgi. Human COG defects lead to severe multisystemic diseases known as COG-congenital disorders of glycosylation (COG-CDG). To gain better understanding of COG-CDGs, we compared COG knockout cells with cells deficient to 2 key enzymes,...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29573151
DOI: 10.1111/tra.12564
PMCID: PMC5948163

Genes

COG7
GALE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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