IFNγ activates an immune-like regulatory network in the cardiac vascular endothelium

Abstract excerpt

The regulatory mechanisms underlying the response to pro-inflammatory cytokines in cardiac diseases are poorly understood. Here, we use iPSC-derived cardiovascular progenitor cells (CVPCs) to model the response to interferon gamma (IFNγ) in human cardiac tissue. We generate RNA-seq and ATAC-seq for four CVPCs that were treated with IFNγ and compare them with paired untreated controls. Transcriptional differences a...

Topics

Open a Topic to create a Post that cites this publication.

• Cardiac Fibrosis and Remodeling
• Cardiovascular Diseases
• CD4-Positive T-Lymphocytes
• CD8-Positive T-Lymphocytes
• Congenital heart defects research
• Cytokine Signaling Pathways and Interactions
• HIV Infections
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

84db5061-1b6d-59d5-a5a5-fefb9d83b428

DOI

10.1101/2024.05.03.592380