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Article

Functional Role of Single-Nucleotide Polymorphisms on IFNG and IFNGR1 in Humans with Cardiovascular Disease.

International journal of molecular sciences - 10 Sept 2025

Mehta Megh, Li Yang, Parashar Smriti, Ramirez Catalina, McKay Heather, Landay Alan, Aherrahrou Redouane, Advani Aarushi, Patel Raag, Kaplan Robert, Lazar Jason, Anastos Kathryn, Hanna David B, Qi Qibin, Ley Klaus

Abstract excerpt

HIV infection is known to increase the risk for cardiovascular disease (CVD). Although almost 400 single-nucleotide polymorphisms (SNPs) are significantly associated with CAD alone, a subtype of CVD, the functions of most of these risk loci are unclear. Here, we investigated the impact of genetic variants/SNPs on the expression of nearby genes as potential cis expression quantitative trait loci (cis-eQTLs). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41009374
DOI: 10.3390/ijms26188806
PMCID: PMC12865476

Genes

IFNG
CD4
IFNGR1
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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