Article

A Population-Scale Single-Cell Atlas of the Human Heart Reveals Cellular Remodeling and Cell–Cell Communication in Aging and Cardiac Disease

2025-12-15

Abstract excerpt

Previous single-cell and single-nucleus heart atlases, often limited by small sample sizes, lack the statistical power needed for phenotype association analysis, particularly for cardiovascular diseases and cardiac aging. To address this, we integrated data from 436 samples across 12 single-cell studies, harmonized the corresponding sample metadata, and constructed a comprehensive heart atlas comprising 355,762 ce...

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Literature Corpus work: 34c6334b-d590-5638-a2b9-5eb2a79edb4c
DOI: 10.64898/2025.12.12.693831

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