Article

Single Cell and Spatial Transcriptomics Identify Novel Immune-Stromal Interactions in Cardiac Allograft Vasculopathy

2025-11-21

Abstract excerpt

<title>Abstract</title> <p>Cardiac allograft vasculopathy (CAV) is the leading cause of mortality in heart transplant recipients. Despite the prevalence of CAV, there are no targeted therapeutic options to prevent or reverse disease progression, and patients ultimately require retransplant. CAV is defined by progressive neointimal hyperplasia in donor heart coronary arteries, leading to luminal obliteration and u...

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Literature Corpus work: ab085b90-864b-5823-915a-d4deddef67c8
DOI: 10.21203/rs.3.rs-7812112/v1

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