Article

BCL6 regulates the endothelial pro-immunogenic phenotype relevant to organ transplant rejection

2022-11-04

Abstract excerpt

<h4>Background</h4> IFNγ induces an endothelial cell pro-immunogenic phenotype through the JAK/STAT1 pathway, which can influence alloreactive leukocytes in transplant rejection. Numerous endogenous suppressors of JAK and STAT activation have been described, but regulation of STAT1 at the level of transcription is not well-understood. In immune cells, the DNA binding protein BCL6 controls transcription of lineage...

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Literature Corpus work: c71ea2e1-1e98-5e0f-b54e-03e0d55ab332
DOI: 10.1101/2022.11.03.514941

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