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Mutation-Induced Pocket Deactivation: How Ser353/Pro245 Alters K <sub>Ca</sub> 2.2 vs K <sub>Ca</sub> 3.1 Ligand Selectivity

2026-05-06

Abstract excerpt

The K Ca 2.2 and K Ca 3.1 channels are fundamental regulator of cellular K + concentration, and promising target to treat diseases such as spinocerebellar ataxia and cancer. To fully exploit their therapeutic potential, and to continue studying their pathophysiological role, it is crucial to develop selective modulators for each of these two channels. Here we present a computational study to identify the molecu...

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Literature Corpus work: 84cee181-a2c4-55fa-a7e3-f4327f4b8d75
DOI: 10.64898/2026.05.03.722491

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Mutation-Induced Pocket Deactivation: How Ser353/Pro245 Alters K <sub>Ca</sub> 2.2 vs K <sub>Ca</sub> 3.1 Ligand SelectivityDOI 10.64898/2026.05.03.722491Read

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