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Mutation-Induced Pocket Deactivation: How Ser353/Pro245 Alters KCa2.2 vs. KCa3.1 Ligand Selectivity.

Archiv der Pharmazie - 1 Jul 2026

Gozzi Matteo, Massa Joana, Koch Oliver

Abstract excerpt

The KCa2.2 and KCa3.1 channels are fundamental regulators of membrane potential and calcium signalling and promising targets to treat diseases such as spinocerebellar ataxia and cancer. To fully exploit their therapeutic potential, and to continue studying their pathophysiological role, it is crucial to develop selective modulators for each of these two channels. Here, we present a computational study to identify...

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PMID: 42458866
DOI: 10.1002/ardp.70299
PMCID: PMC13373493

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