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Article

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction.

eLife - 26 Apr 2021

Lau Eva On-Chai, Damiani Devid, Chehade Georges, Ruiz-Reig Nuria, Saade Rana, Jossin Yves, Aittaleb Mohamed, Schakman Olivier, Tajeddine Nicolas, Gailly Philippe, Tissir Fadel

Abstract excerpt

Diaphanous (DIAPH) three (DIAPH3) is a member of the formin proteins that have the capacity to nucleate and elongate actin filaments and, therefore, to remodel the cytoskeleton. DIAPH3 is essential for cytokinesis as its dysfunction impairs the contractile ring and produces multinucleated cells. Here, we report that DIAPH3 localizes at the centrosome during mitosis and regulates the assembly and bipolarity of the...

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Identifiers

PMID: 33899739
DOI: 10.7554/eLife.61974
PMCID: PMC8102060

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