Article

Aberrant cortical development is driven by impaired cell cycle and translational control in a <i>DDX3X</i> syndrome model

2022-02-21

Abstract excerpt

Mutations in the RNA helicase, DDX3X , are a leading cause of Intellectual Disability and present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical malformations and autism. Yet the cellular and molecular mechanisms by which DDX3X controls cortical development are largely unknown. Here, using a mouse model of Ddx3x loss-of-function we demonstrate that DDX3X directs translational and cel...

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Literature Corpus work: ef1d0167-1375-545f-bb7c-71371eaf3340
DOI: 10.1101/2022.02.21.481343

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