Article

The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton

2022-03-19

Abstract excerpt

<h4>Summary</h4> The exon junction complex (EJC), nucleated by EIF4A3, is indispensable for mRNA fate and function throughout eukaryotes. Unexpectedly, we discover that EIF4A3 directly controls microtubules independent of RNA, and this is critical for neural wiring. While neuronal survival in the developing mouse cerebral cortex depends upon an intact EJC, axonal tract formation requires only Eif4a3 . Using huma...

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Literature Corpus work: 026b0569-57ab-50cb-98d3-e600eaea1654
DOI: 10.1101/2022.03.18.484888

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