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Article

Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon

1 Apr 2004

Abstract excerpt

BACKGROUND: The ability to discern ancestral relationships between individual human colon crypts is limited. Widely separated crypts likely trace their common ancestors to a time around birth, but closely spaced adult crypts may share more recent common ancestors if they frequently divide by fission to form clonal patches. Alternatively, adult crypts may be long-lived structures that infrequently divide or die....

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PMID: 15059289
DOI: 10.1186/1471-230x-4-8

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