Article

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia

2018-01-16

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Treatments 1-6 show high response rates but have debilitating effects and carry risk of relapse 5,7,8 . Previous work implicated NOTCH1 and other oncogenes 1,2,9-20 . However, direct inhibition of these pathways affects healthy tissues and cancer alike. Here, we demonstrate that ubiquitin-specific protease 7 (US...

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Literature Corpus work: 847b28a4-329c-5051-a926-b463e89ff9d1
DOI: 10.1101/248427

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