Recent advances on NOTCH signaling in T-ALL.

Abstract excerpt

NOTCH1 receptor signaling plays a central role in T-cell lineage specification and in supporting the growth and proliferation of immature T-cell progenitors in the thymus during lymphoid development. In T-cell acute lymphoblastic leukemia (T-ALL), a tumor resulting from the malignant transformation of T-cell progenitors, aberrant and constitutively active NOTCH1 signaling triggered by activating mutations in the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Receptor, Notch1
• Share to Amyloid Precursor Protein Secretases
• Share to Antibodies