Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia

Abstract excerpt

Abstract Splicing alterations are common in diseases such as cancer, where mutations in splicing factor genes are frequently responsible for aberrant splicing. Here we present an alternative mechanism for splicing regulation in T-cell acute lymphoblastic leukemia (T-ALL) that involves posttranslational stabilization of the splicing machinery via deubiquitination. We demonstrate there are extensive exon skipping...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related gene regulation
• Share to Lymphoma Diagnosis and Treatment
• Share to RNA modifications and cancer