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Article

WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia

13 Mar 2019

Abstract excerpt

BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature T-cell progenitors with poor outcomes. WP1130 has shown potent activity against a variety of cancer but whether WP1130 has anti-T-ALL activity is not clear. USP24, one target of WP1130, is one of the largest deubiquitinases and its detailed mechanism is poorly understood. The aim of...

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PMID: 30911287
DOI: 10.1186/s12935-019-0773-6

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