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Article

Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders

29 Apr 2016

Abstract excerpt

PURPOSE OF REVIEW: This article highlights recent discoveries about Notch activation and its oncogenic functions in lymphoid malignancies, and discusses the therapeutic potential of Notch inhibition. RECENT FINDINGS: NOTCH mutations arise in a broad spectrum of lymphoid malignancies and are increasingly scrutinized as putative therapeutic targets. In T-cell acute lymphoblastic leukemia (T-ALL), NOTCH1 mutations...

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PMID: 27135981
DOI: 10.1097/moh.0000000000000254

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