Article
Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children.
Journal of the National Cancer Institute - 1 Dec 2019
Qian Maoxiang, Zhao Xujie, Devidas Meenakshi, Yang Wenjian, Gocho Yoshihiro, Smith Colton, Gastier-Foster Julie M, Li Yizhen, Xu Heng, Zhang Shouyue, Jeha Sima, Zhai Xiaowen, Sanda Takaomi, Winter Stuart S, Dunsmore Kimberly P, Raetz Elizabeth A, Carroll William L, Winick Naomi J, Rabin Karen R, Zweidler-Mckay Patrick A, Wood Brent, Pui Ching-Hon, Evans William E, Hunger Stephen P, Mullighan Charles G, Relling Mary V, Loh Mignon L, Yang Jun J
Abstract excerpt
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common cancer in children and can arise in B or T lymphoid lineages. Although risk loci have been identified for B-ALL, the inherited basis of T-ALL is mostly unknown, with a particular paucity of genome-wide investigation of susceptibility variants in large patient cohorts. METHODS: We performed a genome-wide association study (GWAS) in 1191 children...
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