Article
Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads.
BMC genomics - 1 May 2014
Bai Yu, Ni Min, Cooper Blerta, Wei Yi, Fury Wen
Abstract excerpt
BACKGROUND: Accurate HLA typing at amino acid level (four-digit resolution) is critical in hematopoietic and organ transplantations, pathogenesis studies of autoimmune and infectious diseases, as well as the development of immunoncology therapies. With the rapid adoption of genome-wide sequencing in biomedical research, HLA typing based on transcriptome and whole exome/genome sequencing data becomes increasingly...
Topics
- Algorithms
- Alleles
- DNA
- Genome, Human
- HLA Antigens
- Humans
- RNA