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Cost-Effective and Highly Scalable Typing of HLA Classes I and II Genes of up to 96 Individuals Using Nanopore Sequencing.

HLA - 1 Apr 2025

Pedersen Frederikke Byron, Hauge Anne Werner, Hansen Jacob Flemming, Andersen Laura Studnitz, Blomsterberg Signe, Bruunsgaard Helle

Abstract excerpt

HLA typing of large donor registries and biobanks as well as acute single patient/donor samples remains expensive, slow and logistically challenging, despite recent developments in the field. We have tested and validated a cost-effective, accurate and highly scalable method for typing specific genes in the HLA region. This enables HLA typing from 1 to 96 individuals simultaneously, using a targeted PCR and Native...

Read the complete abstract on PubMed

Topics

Humans
Histocompatibility Testing
Nanopore Sequencing
Cost-Benefit Analysis
Alleles
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Multiplex Polymerase Chain Reaction

Source

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Identifiers

PMID: 40270210
DOI: 10.1111/tan.70164
PMCID: PMC12019580

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