Article

Systematic differences in protein stability underlie species-specific developmental tempo

2024-06-08

Abstract excerpt

Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model to study interspecies differences in developmental tempo, as its oscillation period in human induced presomitic mesoderm (iPSM) cells is approximately twice that of mouse. While the core clock gene HES7 exhibits slower protein degradation in human cells, it remains unclear whether such cross-species diffe...

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Literature Corpus work: 01080158-2732-5ec0-a6a1-0e5b5bdc6baa
DOI: 10.1101/2024.06.07.597977

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