Article

Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation

2017-01-31

Abstract excerpt

Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these limitations, we developed Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS), and validated its ability to identify distinct human cancer cell types b...

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Literature Corpus work: d3864b5c-8d85-552c-a7c9-64d13abb308e
DOI: 10.7287/peerj.preprints.2767v1

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