Back to search

Article

LRP6-Guided Engineering of AAV9 Variants with Enhanced Blood-Brain Barrier Penetration and Reduced Liver Tropism in Non-Human Primates

2026-03-18

Abstract excerpt

<h4>ABSTRACT</h4> The blood-brain barrier (BBB) severely restricts the delivery of systemically administered adeno-associated virus (AAV) vectors for central nervous system (CNS) gene therapy. To overcome this limitation, we engineered a library of AAV9 capsid variants through rational design focused on the low-density lipoprotein receptor-related protein 6 (LRP6), a conserved mediator of transcytosis. A multi-ti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ae90cfef-d819-51a8-b41a-b88b6b0730b3
DOI
10.64898/2026.03.15.711945
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
LRP6-Guided Engineering of AAV9 Variants with Enhanced Blood-Brain Barrier Penetration and Reduced Liver Tropism in Non-Human PrimatesDOI 10.64898/2026.03.15.711945
Novel Engineered AAV Variants Demonstrate Superior Blood-Brain Barrier Penetration and Safety in Non-Human PrimatesSemantic proximity
New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosetsSemantic proximity
Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsidsSemantic proximity
Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids.Semantic proximity
AAV Engineering for Improving Tropism to the Central Nervous SystemSemantic proximity
Characterization of brain transduction capability of a BBB-penetrant, peptide-displaying AAV vector in mice, rats and non-human primatesSemantic proximity
Identification of AAV Capsids with Enhanced Intravitreal Transduction and Favorable Safety Profile in Non-Human PrimatesSemantic proximity
Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedsideSemantic proximity
Selection of rAAV Vectors that Cross the Human Blood-Brain Barrier and Target the Central Nervous System Using a Transwell ModelSemantic proximity
Highly conserved brain vascular receptor ALPL mediates transport of engineered viral vectors across the blood-brain barrierSemantic proximity
Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binderSemantic proximity
Routes of administration for adeno-associated viruses carrying gene therapies for brain diseasesSemantic proximity
Select a neighboring publication to make it the new centre.