Article

Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion

2025-01-24

Abstract excerpt

<h4>SUMMARY</h4> Several alphaviruses bypass the blood-brain barrier (BBB), causing debilitating or fatal encephalitis. Sindbis virus (SINV) has been extensively studied in vivo to understand alphavirus neuropathogenesis; yet the molecular details of neuroinvasion at the BBB remain poorly understood. We investigated alphavirus-BBB interactions by pairing a physiologically relevant, human pluripotent stem cell de...

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Literature Corpus work: 0f16575d-8c89-50c4-8d1c-ecf88f0e23d8
DOI: 10.1101/2025.01.22.634395

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