Article

Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoids

2023-04-13

Abstract excerpt

Human-derived cortical organoids (hCOs) recapitulate cell diversity and 3D structure found in the human brain and offer a promising model for discovery of new gene therapies targeting neurological disorders. Adeno-associated viruses (AAVs) are the most promising vehicles for non-invasive gene delivery to the central nervous system (CNS), but reliable and reproducible in vitro models to assess their clinical poten...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1188f985-1238-5178-8e1f-8d2f02c45bda
DOI: 10.1101/2023.04.13.536491

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoidsDOI 10.1101/2023.04.13.536491Read

Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell typesSemantic proximity Read

Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated VirusSemantic proximity Read

Comprehensive investigation of AAV tropism across human iPSC-derived neuronal subtypesSemantic proximity Read

Applications of adeno-associated virus for 3D single-cell morphometric analysis in iPSC-derived midbrain organoidsSemantic proximity Read

A fully human pluripotent stem cell-derived blood-brain barrier model for clinically relevant disease modeling and selection of neurotropic adeno-associated virusesSemantic proximity Read

Identification of Adeno-Associated Virus Variants for Gene Transfer Into Human Neural Cell Types by Parallel Capsid ScreeningSemantic proximity Read

Biology of adeno-associated viral vectors in the central nervous systemSemantic proximity Read

Adeno-Associated Virus (AAV) Vectors in the CNSSemantic proximity Read

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem CellsSemantic proximity Read

SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoidsSemantic proximity Read

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates, and humansSemantic proximity Read

Modeling neurological disorders using brain organoids.Semantic proximity Read