Article

Polygenic Adaptation has Impacted Multiple Anthropometric Traits

2017-07-23

Abstract excerpt

Our understanding of the genetic basis of human adaptation is biased toward loci of large pheno-typic effect. Genome wide association studies (GWAS) now enable the study of genetic adaptation in polygenic phenotypes. We test for polygenic adaptation among 187 world-wide human populations using polygenic scores constructed from GWAS of 34 complex traits. We identify signals of polygenic adaptation for anthropometri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 034c6942-a719-5cc7-aa0f-6d801ce6bac9
DOI: 10.1101/167551

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic Adaptation has Impacted Multiple Anthropometric TraitsDOI 10.1101/167551Read

How robust are cross-population signatures of polygenic adaptation in humans?Semantic proximity Read

Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studiesSemantic proximity Read

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selectionSemantic proximity Read

Evidence of polygenic adaptation at height-associated loci in mainland Europeans and SardiniansSemantic proximity Read

Evidence of Polygenic Adaptation in Sardinia at Height-Associated Loci Ascertained from the Biobank Japan.Semantic proximity Read

Allele frequency differentiation at height-associated SNPs among continental human populations.Semantic proximity Read

Analysis of Polygenic Score Usage and Performance in Diverse Human PopulationsSemantic proximity Read

Allele frequency differentiation at height-associated SNPs among continental human populationsSemantic proximity Read

The importance of including ethnically diverse populations in studies of quantitative trait evolution.Semantic proximity Read

From Galton to GWAS: quantitative genetics of human height.Semantic proximity Read

A saturated map of common genetic variants associated with human height.Semantic proximity Read

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse AncestriesSemantic proximity Read