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Article

E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions.

International journal of molecular sciences - 12 Nov 2020

Brunet Manon, Vargas Claire, Larrieu Dorian, Torrisani Jérôme, Dufresne Marlène

Abstract excerpt

The Thyroid hormone Receptor Interacting Protein 12 (TRIP12) protein belongs to the 28-member Homologous to the E6-AP C-Terminus (HECT) E3 ubiquitin ligase family. First described as an interactor of the thyroid hormone receptor, TRIP12's biological importance was revealed by the embryonic lethality of a murine model bearing an inactivating mutation in the TRIP12 gene. Further studies showed the participation of...

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Identifiers

PMID: 33198194
DOI: 10.3390/ijms21228515
PMCID: PMC7697007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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