Article
Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis.
Cell reports - 28 Mar 2017
Chen Liang, Brewer Michael D, Guo Lili, Wang Ruoxing, Jiang Peng, Yang Xiaolu
Abstract excerpt
An adequate cellular capacity to degrade misfolded proteins is critical for cell survival and organismal health. A diminished capacity is associated with aging and neurodegenerative diseases; however, the consequences of an enhanced capacity remain undefined. Here, we report that the ability to clear misfolded proteins is increased during oncogenic transformation and is reduced upon tumor cell differentiation....
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