Article

Spatial tumor microenvironmental architecture of chemoradiotherapy-resistant residual esophageal squamous cell carcinoma

2026-06-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Residual ESCC after neoadjuvant CCRT reflects incomplete treatment response and carries a high risk of recurrence. We sought to define the spatial tumor microenvironmental features of CCRT-resistant residual ESCC — using tumor regression grade (TRG) 2–3 tumors as a model of poor pathologic response — with mechanistic refinement at single-cell resolution and outcome assessment i...

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Literature Corpus work: 1095ff91-dc29-5600-af27-deebeff28517
DOI: 10.64898/2026.06.01.729308

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