Article

Multi-Omics Reveals Activated Fibroblasts with Dual Functional Roles in Repair and Negative Barrier in the CD8 <sup>+</sup> T Cell Cytotoxic Niche for Lung Cancer Neoadjuvant Therapy

2026-01-15

Abstract excerpt

<h4>ABSTRACT</h4> A major challenge in elucidating immune activation and tolerance is that single-omics technologies are inherently limited. Since single-cell transcriptomics lacks spatial information and spatial transcriptomics lacks resolution or depth, neither can adequately model the multidimensional tumor immune microenvironment (TiME) features. We present NICHE (Niche Integrated Cellular Heterogeneity Eluci...

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Literature Corpus work: 1b3089d4-2d55-58d0-a1c3-8546d520fb3c
DOI: 10.64898/2026.01.14.699401

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Multi-Omics Reveals Activated Fibroblasts with Dual Functional Roles in Repair and Negative Barrier in the CD8 <sup>+</sup> T Cell Cytotoxic Niche for Lung Cancer Neoadjuvant TherapyDOI 10.64898/2026.01.14.699401Read

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