Article
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer.
Cancer cell - 12 Jan 2026
Marteau Valentin, Nemati Niloofar, Handler Kristina, Raju Deeksha, Kirchmair Alexander, Rieder Dietmar, Kvalem Soto Erika, Fotakis Georgios, De Lange Glenn, Carollo Sandro, Boeck Nina, Rossi Alessia, Daum Sophia, Scheiber Alexandra, Amann Arno, Seeber Andreas, Gasser Elisabeth, Ormanns Steffen, Günther Michael, Martowicz Agnieszka, Loncova Zuzana, Lamberti Giorgia, Krogsdam Anne, Carlet Michela, Horvath Lena, Eling Marie Theres, Fazilaty Hassan, Valenta Tomas, Sturm Gregor, Sopper Sieghart, Pircher Andreas, Stoitzner Patrizia, Wild Peter J, Welker Patrick, May Pascal J, Ziegler Paul, Tschurtschenthaler Markus, Neureiter Daniel, Huemer Florian, Greil Richard, Weiss Lukas, Ijsselsteijn Marieke, de Miranda Noel F C C, Wolf Dominik, Arnold Isabelle C, Salcher Stefan, Trajanoski Zlatko
Abstract excerpt
The immune composition of the tumor microenvironment has a major impact on the therapy response in patients with colorectal cancer. Here, we built an atlas with 4.27 million single cells from 1,670 patient samples and complemented it with single-cell profiles from 266 patients, including cells with low mRNA content, spatial transcriptomics from 3.7 million cells, and protein profiles from 0.7 million cells. The...
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