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Article

Parent-of-origin effects in Alzheimer's liability dissociate neurocognitive and cardiovascular traits in at-risk individuals.

Cell reports. Medicine - 18 Aug 2026

Savignac Chloé, St-Onge Frédéric, Villeneuve Sylvia, Badhwar AmanPreet, Gagliano Taliun Sarah A, Farhan Sali, Geddes Maiya, Iturria Medina Yasser, Poirier Judes, Spreng R Nathan, Bzdok Danilo

Abstract excerpt

Alzheimer's disease (AD) has a higher prevalence in women than men and is more frequently inherited from mothers than fathers. Yet, while neuroimaging and biomarker studies link maternal family history to stronger AD-related alterations, epidemiological studies suggest that paternal history confers comparable or even greater risk. Here, we leverage the deeply profiled PREVENT-AD cohort to derive three...

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Identifiers

PMID: 42520805
DOI: 10.1016/j.xcrm.2026.102943
PMCID: PMC13522784

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