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Article

Interpretation of 10 years of Alzheimer's disease genetic findings in the perspective of statistical heterogeneity.

Briefings in bioinformatics - 27 Mar 2024

Gao Shan, Wang Tao, Han Zhifa, Hu Yang, Zhu Ping, Xue Yanli, Huang Chen, Chen Yan, Liu Guiyou

Abstract excerpt

Common genetic variants and susceptibility loci associated with Alzheimer's disease (AD) have been discovered through large-scale genome-wide association studies (GWAS), GWAS by proxy (GWAX) and meta-analysis of GWAS and GWAX (GWAS+GWAX). However, due to the very low repeatability of AD susceptibility loci and the low heritability of AD, these AD genetic findings have been questioned. We summarize AD genetic...

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PMID: 38711368
DOI: 10.1093/bib/bbae140
PMCID: PMC11074593

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