Article
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
Nature - 7 Apr 2011
Wang Zeneng, Klipfell Elizabeth, Bennett Brian J, Koeth Robert, Levison Bruce S, Dugar Brandon, Feldstein Ariel E, Britt Earl B, Fu Xiaoming, Chung Yoon-Mi, Wu Yuping, Schauer Phil, Smith Jonathan D, Allayee Hooman, Tang W H Wilson, DiDonato Joseph A, Lusis Aldons J, Hazen Stanley L
Abstract excerpt
Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death and morbidity worldwide. Here we used a metabolomics approach to generate unbiased small-molecule metabolic profiles in plasma that predict risk for CVD. Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and...
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