Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases.

Nutrients - 5 Aug 2020

Arias Natalia, Arboleya Silvia, Allison Joseph, Kaliszewska Aleksandra, Higarza Sara G, Gueimonde Miguel, Arias Jorge L

Abstract excerpt

Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host is converted into trimethylamine-N-oxide (TMAO) in the liver. A high accumulation of both components is related to cardiovascular disease, inflammatory bowel disease, non-alcoholic fatty liver disease, and chronic kidney disease....

Topics

Join the communities discussing this publication.

Biological Availability
Choline
Dysbiosis
Gastrointestinal Microbiome
Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Non-alcoholic Fatty Liver Disease

Renal Insufficiency, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 32764281
DOI: 10.3390/nu12082340
PMCID: PMC7468957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases.PMID 32764281Read ↗

Trimethylamine- N -oxide formation, the bacterial taxa involved and intervention strategies to reduce its concentration in the human bodySemantic proximity Read ↗

Choline metabolitesSemantic proximity Read ↗

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolismSemantic proximity Read ↗

TMAO and its precursors in relation to host genetics, gut microbial composition, diet, and clinical outcomes: Meta-analysis of 5 prospective population-based cohortsSemantic proximity Read ↗

The gene expression and bioinformatic analysis of choline trimethylamine-lyase (CutC) and its activating enzyme (CutD) for gut microbes and comparison with their TMA production levelsSemantic proximity Read ↗

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism.Semantic proximity Read ↗

Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population levelSemantic proximity Read ↗

Uncovering the trimethylamine-producing bacteria of the human gut microbiotaSemantic proximity Read ↗

Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3Semantic proximity Read ↗

Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gutSemantic proximity Read ↗

Dysbiosis of Gut Microbiota with Increased Trimethylamine N-oxide Level in Patients with Large Artery Atherosclerotic and Cardioembolic StrokesSemantic proximity Read ↗

Choline Metabolism to the Proatherogenic Metabolite Trimethylamine Occurs Primarily in the Distal Regions of the MiGut 3-Compartment <em>In Vitro</em> Colon Microbiome ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.