Article

Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3

2023-04-22

Abstract excerpt

<h4>ABSTRACT</h4> High circulating levels of trimethylamine N-oxide (TMAO) have been associated with cardiovascular disease risk. TMAO is formed through a microbiome-host pathway utilizing primarily dietary choline as a substrate. Specific gut microbiota transform choline into trimethylamine (TMA), and, when absorbed, host hepatic flavin-containing monooxygenase 3 (FMO3) oxidizes TMA into TMAO. Chlorogenic acid a...

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Literature Corpus work: 7bab3647-e917-5390-a83c-9bbd656a3d0d
DOI: 10.1101/2023.04.21.537826

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