Article

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

2024-11-09

Abstract excerpt

<h4>Summary</h4> Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host’s impaired ability to oxidize TMA to trimethylamine- N -oxide (TMAO) results in trimethylaminuria (TMAU), while elevated serum TMAO levels have been positively correlated with cardiometabolic disease. Small molecule inhibition of gut bacterial choline metabolism a...

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Literature Corpus work: 1bdffead-a4e7-5104-bf06-4089a14ba8d5
DOI: 10.1101/2024.11.08.621386

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