Computational AOP modeling links 1-nitropyrene exposure to asthma exacerbation and COPD progression

Abstract excerpt

<title>Abstract</title> <p>Nitropyrene (1-NP), a PM2.5-bound nitro-PAH, is a high-priority air pollutant with genotoxic and inflammatory potential, but the cascade linking exposure to asthma exacerbation and COPD progression remains unclear. We developed a multiscale computational respiratory toxicology pipeline integrating network toxicology, clinical transcriptomics, machine-learning feature selection with SHAP...

Topics

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• Air Quality and Health Impacts
• Clustering Algorithms
• Gene Regulatory Networks
• Lung
• Oxidative Stress
• Predictive Learning Models
• Pulmonary Disease, Chronic Obstructive
• Reactive Oxygen Species

Identifiers and source

Literature Corpus work

83c3e3cd-2252-5d03-8348-d6489c289b31

DOI

10.21203/rs.3.rs-8819144/v1