Article

Toxic Mechanisms of PM2.5 Constituents (LPS and BPDE) in Cardiometabolic Disease: Insights from Integrated Machine Learning and Molecular Dynamic Simulations

2025-11-05

Abstract excerpt

<title>Abstract</title> <p>Exposure to specific ambient pollutants, including certain PM2.5-bound constituents like benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) and lipopolysaccharide (LPS), has been increasingly implicated as a significant risk factor in the global burden of cardiometabolic diseases (CMD). However, the precise toxicological mechanisms through which these pollutants adversely affect cardiom...

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Literature Corpus work: edd29cfc-7d8f-53d8-8345-8971b1ec6232
DOI: 10.21203/rs.3.rs-7937700/v1

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