Identification and Functional Characterization of COPD Molecular Subtypes Based on Oxeiptosis-Related Genes via WGCNA and Machine Learning.

doi:10.2147/COPD.S596477

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Article

Identification and Functional Characterization of COPD Molecular Subtypes Based on Oxeiptosis-Related Genes via WGCNA and Machine Learning.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Chen Wenlong, Zhao Jie, Sun Zhigang, Zhou Xingye, Zhang Xingzi, Yan Zhen

Abstract excerpt

Background: This study establishes the first molecular stratification framework for chronic obstructive pulmonary disease (COPD) based on oxeiptosis biology, exploring how this reactive oxygen species (ROS)-induced cell death pathway shapes disease heterogeneity. The precise role of oxeiptosis in COPD pathogenesis remains poorly understood. Methods: Transcriptomic profiles from two independent cohorts, GSE47460...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42273328
DOI: 10.2147/COPD.S596477
PMCID: PMC13248964

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