Article

Network Toxicology and Bioinformatics Reveal Synovial Immune-Inflammatory Mechanisms of DEHP/DBP in Osteoarthritis

2025-11-18

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Osteoarthritis (OA) is increasingly recognized as an immune-inflammatory disease of the joint, with synovial dysfunction contributing to cartilage degeneration. Phthalate plasticizers such as di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) are ubiquitous environmental toxicants; however, their potential association with synovial immune perturbat...

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Literature Corpus work: ae0373b5-2a2f-51d9-993a-98e952b1e36d
DOI: 10.21203/rs.3.rs-7815618/v1

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