Article

Dual-Domain Respiratory Exposome and Airway Epithelial Barrier Dysfunction in Chronic Respiratory Diseases

2026-08-25

Abstract excerpt

The airway epithelial barrier (AEB) is a critical transducer that maintains respiratory homeostasis. This review proposes a novel dual-domain respiratory exposome framework that conceptualizes how the external exposome (cumulative inhaled exposures) and the internal exposome (endogenous immune, metabolic, and endocrine networks) converge to modulate epithelial resilience dynamically. Excessive cumulative pressure...

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Literature Corpus work: 7ffd414b-47b8-5d84-b9a5-a4a96e020b8e
DOI: 10.20944/preprints202508.1426.v2

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