Article

The Tobacco Carcinogen NNK Promotes Idiopathic Pulmonary Fibrosis through Cell Type-Specific Transcriptional Reprogramming and Direct Protein Interactions

2026-05-06

Abstract excerpt

<title>Abstract</title> <p>Idiopathic pulmonary fibrosis (IPF) is strongly associated with cigarette smoking, yet the contribution of the tobacco-specific nitrosamine nicotine-derived nitrosamine ketone (NNK) to IPF mechanisms remains unclear. Here, we integrated chemogenomic target prediction with lung transcriptomics to define exposure-linked, cell type–resolved programs in IPF. Putative human protein targets o...

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Literature Corpus work: 15e641e2-1a90-5e92-9c1f-2526cd697227
DOI: 10.21203/rs.3.rs-9392286/v1

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