Article

Discovery of molecular glues that bind FKBP12 and novel targets using DNA-barcoded libraries

2024-12-12

Abstract excerpt

<h4>ABSTRACT</h4> Molecular glues are small molecules that engage their target and presenter proteins cooperatively. FKBP12 molecular glues (FK506 and rapamycin) were discovered several decades ago and have been used clinically, but our understanding of the breadth of FKBP12 molecular glues and targets has yet to be fully revealed. To identify novel targets of FKBP12 molecular glues, we constructed and screened a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 839d82f8-d204-5d1c-a0b1-8aae219d558f
DOI: 10.1101/2024.12.09.627499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of molecular glues that bind FKBP12 and novel targets using DNA-barcoded librariesDOI 10.1101/2024.12.09.627499Read

CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16Semantic proximity Read

GlueFinder: A Data-Driven Framework for the Rational Discovery of Molecular GluesSemantic proximity Read

Current progress and novel strategies that target CDK12 for drug discovery.Semantic proximity Read

A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbationSemantic proximity Read

Engineered Peptide Barcodes for In-Depth Analyses of Binding Protein EnsemblesSemantic proximity Read

Identification of Suitable Target/E3 Ligase Pairs for PROTAC Development using a Rapamycin-induced Proximity Assay (RiPA)Semantic proximity Read

De novo Design of Macrocyclic Molecular GluesSemantic proximity Read

Integrated proteomic screening reveals design principles of CRBN molecular glue degradersSemantic proximity Read

Modular RNA-based PROTACs for selective degradation of multidomain RNA-binding proteinsSemantic proximity Read

BoltzProt-1: Towards Efficient De Novo Binder Design with Good DevelopabilitySemantic proximity Read

Hijacking the transcriptional activation potential of the BAF complex via Induced ProximitySemantic proximity Read

Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κBSemantic proximity Read