Article

Cell Ploidy Modulates Nucleolar Size via Dosage of Nucleolar Organizing Regions

2026-02-16

Abstract excerpt

Abnormal nucleolar morphology is a pathognomonic histologic feature of cancer cells. Nucleoli are biomolecular condensates and cytogenetic entities that form around nucleolar organizing regions (NORs), located on the short arms of acrocentric chromosomes. Given that aneuploidy is pervasive in human cancers and can involve NOR-bearing chromosomes, we investigated how aneuploidy-driven changes in NOR dosage impact n...

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Literature Corpus work: 839bd3bc-6c83-5e80-b958-eac88c8c0e3d
DOI: 10.64898/2026.02.13.705825

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