Article

Every single conidium in <i>Aspergillus fumigatus</i> caspofungin tolerant strains are intrinsically caspofungin tolerant

2022-02-19

Abstract excerpt

Aspergillus fumigatus is a human fungal pathogen that causes a disease named aspergillosis. Echinocandins, such as the fungistatic drug caspofungin (CAS) are used as second-line therapy. Some A. fumigatus clinical isolates can survive and grow in higher CAS concentrations, a phenomenon known as “caspofungin paradoxical effect” (CPE). Here we investigate if CPE is due to a subpopulation of conidia produced by a CA...

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Literature Corpus work: 839121ba-65df-5bcb-a0a1-0c215bde757b
DOI: 10.1101/2022.02.17.480978

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