Article

Echinocandin tolerance and persistence <i>in vitro</i> are regulated by calcineurin signaling in <i>Candida glabrata</i>

2025-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Upon exposure to echinocandins, growing yeast cells begin to accumulate cell wall damage and eventually die, resulting in therapeutic effects. While resistance to echinocandins is well studied, tolerance and persistence mechanisms that may also contribute to clinical failures and relapses remain understudied. In time-kill assays with micafungin in vitro , the opportunistic pathogen Candida gla...

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Literature Corpus work: 19f48bbf-9278-508d-bcc5-ed171ac245fb
DOI: 10.1101/2025.08.19.671059

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