Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

30 Oct 2021

Abstract excerpt

Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA), a severe disease that affects immunosuppressed patients worldwide. The fungistatic drug caspofungin (CSP) is the second line of therapy against IPA but has increasingly been used against clinical strains that are resistant to azoles, the first line antifungal therapy. In high concentrations, CSP induces a tolerance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal Biology and Applications
Share to Microbial Natural Products and Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34718550
DOI: 10.1093/genetics/iyab183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofunginPMID 34718550Read ↗

Heterogeneity in the transcriptional response of the human pathogen <i>Aspergillus fumigatus</i> to the antifungal agent caspofunginSemantic proximity Read ↗

Strain variation in the Candida albicans iron limitation response.Semantic proximity Read ↗

The Transcriptome Response to Azole Compounds in Aspergillus fumigatus Shows Differential Gene Expression across Pathways Essential for Azole Resistance and Cell SurvivalSemantic proximity Read ↗

Global Transcriptome Changes Underlying Colony Growth in the Opportunistic Human Pathogen Aspergillus fumigatusSemantic proximity Read ↗

Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human Pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinisSemantic proximity Read ↗

<i>Aspergillus fumigatus</i> versus Genus <i>Aspergillus</i> : Conservation, adaptive evolution and specific virulence genesSemantic proximity Read ↗

Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent MannerSemantic proximity Read ↗

Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species ComparisonSemantic proximity Read ↗

Genomic and phenotypic heterogeneity of clinical isolates of the human pathogens <i>Aspergillus fumigatus, Aspergillus lentulus</i> and <i>Aspergillus fumigatiaffinis</i>Semantic proximity Read ↗

Heterogeneity Confounds Establishment of "a" Model Microbial Strain.Semantic proximity Read ↗

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatusSemantic proximity Read ↗

The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.