Article

Identification and Elimination of Antifungal Tolerance in <i>Candida auris</i>

2022-12-22

Abstract excerpt

Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance. Fluconazole failure in C. auris has been recently attributed to antifungal “tolerance”. Tolerance is a phenomenon whereby a slow growing subpopulation of toleran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eea6deca-3f9e-5434-8412-cd35f67ff0f6
DOI: 10.1101/2022.12.22.521687

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification and Elimination of Antifungal Tolerance in <i>Candida auris</i>DOI 10.1101/2022.12.22.521687Read

Clearing the FoG: Antifungal tolerance is a subpopulation effect that is distinct from resistance and is associated with persistent candidemiaSemantic proximity Read

Broad sensitivity of <i>Candida auris</i> strains to quinolones and mechanisms of resistanceSemantic proximity Read

What makes <i>Candida auris</i> pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugsSemantic proximity Read

Combined genetic and environmental factors shape the landscape of anti-fungal tolerance in Nakaseomyces glabratusSemantic proximity Read

Genomic diversity across <i>Candida auris</i> clinical isolates shapes rapid development of antifungal resistance <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Every single conidium in <i>Aspergillus fumigatus</i> caspofungin tolerant strains are intrinsically caspofungin tolerantSemantic proximity Read

The stress-protectant molecule trehalose mediates fluconazole tolerance in <i>Candida glabrata</i>Semantic proximity Read

Microevolution of clade II isolates of <i>Candida auris</i> highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin BSemantic proximity Read

<i>In vivo</i> evolution of <i>Candida auris</i> multi-drug resistance in a patient receiving antifungal treatmentSemantic proximity Read

Antarctic marine microplastics reveals environmental persistence and rapid evolution of <i>Candida auris</i>Semantic proximity Read

Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>Semantic proximity Read

<i>In vivo</i> emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in <i>Candida auris</i>Semantic proximity Read