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Aspergillus terreus and the Interplay with Amphotericin B: from Resistance to Tolerance?

7 Mar 2022

Abstract excerpt

antifungal susceptibility (AFST) and the fungicidal activity of AMB against 100 clinical isolates of A. terreus species complex in RPMI 1640 and antibiotic medium 3 (AM3). MICs ranged from 0.5 to 16 μg/mL for RPMI 1640 and from 1 to >16 mg/L for AM3. AMB showed medium-dependent activity, with fungicidal effects only in antibiotic medium 3, not in RPMI 1640. Furthermore, the presence of AMB-tolerant phenotypes of...

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PMID: 35254091
DOI: 10.1128/aac.02274-21

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